Officials released early findings as the mayor confirmed the death toll following a cargo plane crash near Louisville Muhammad Ali International Airport. Federal investigators reported that the left engine of a UPS MD-11F detached during takeoff, causing the aircraft to crash just beyond the runway. Several people were killed in the aftermath.

Plumes of fire and smoke rose from the site on November 4, 2025, shocking the community. Video footage and physical evidence guided the National Transportation Safety Board (NTSB) to their initial conclusions.

Flight Struggled After Takeoff
The crash occurred around 5:15 p.m. as the MD-11F was en route to Honolulu. NTSB spokesperson Todd Inman said, “The plane lifted off, cleared the fence at the end of Runway 17R, but shortly after, it struck structures and terrain off airport property.”

The plane’s violent impact and the left engine separation caused massive damage. CBS News’ Kris Van Cleave explained, “That 5-ton engine was thrown across the runway and into the grass area on the right side.” Debris likely damaged the right wing, raising concerns that two engines may have malfunctioned during takeoff.