Some of the strange signs people experience include persistent puffy eyes, unusually strong cravings for ice, metallic taste in the mouth, or breath that smells like ammonia. Others notice swelling in unexpected places like the ankles, hands, or even around the abdomen. Sudden nighttime muscle cramps, itchy skin with no rash, and foamier-than-usual urine can also point toward kidney strain. Even seemingly harmless issues — such as difficulty concentrating, unexplained fatigue, or a drop in appetite — may be quietly connected to declining kidney function.

More unusual symptoms can include changes in skin color, increased sensitivity to cold, feeling short of breath, or experiencing dizziness every time you stand. Some people report flank pain that comes and goes, restless sleep, or waking up repeatedly to urinate. Mood changes, especially irritability or anxiety, can also occur when toxins begin to build up in the bloodstream. While these symptoms don’t always mean something serious, they become more concerning when they occur together or persist over time.

Recognizing these 23 strange signs early — from swelling and skin changes to unusual cravings, foggy thinking, and shifts in bathroom habits — can make a dramatic difference in protecting your kidney health. While only a medical professional can determine the true cause, staying aware of your body’s signals is a powerful first step. Your kidneys may be quiet, but they’re always communicating — and knowing what to look for can help you act before small problems become much bigger ones.