Jennifer Lopez has shared her favorite on-screen kiss, and fans were not expecting her answer. The rom-com veteran weighed in on six Hollywood heartthrobs before giving a surprising pick from her latest Netflix project.

Playing “Plead the Fifth”
In October 2025, Lopez appeared on Watch What Happens Live with Andy Cohen. During the popular “Plead the Fifth” game, Cohen pressed her to reveal her favorite on-screen kiss. He listed former co-stars George Clooney, Matthew McConaughey, Ralph Fiennes, Richard Gere, Owen Wilson, and Josh Lucas.

Iconic Chemistry with George Clooney
Many fans still remember Lopez’s sizzling pairing with George Clooney in Steven Soderbergh’s 1998 film Out of Sight. Publicity photos highlighted their undeniable chemistry, making the movie a standout in her early rom-com career.

Box Office Magic with Matthew McConaughey
In 2001, Lopez starred in The Wedding Planner with Matthew McConaughey. The film became a box office hit and cemented her status as a beloved romantic comedy leading lady.